You can't miss those Top 10 malaria-free safari lodges in Africa!
SEE.AFRICA SELECTION

You can't miss those Top 10 malaria-free safari lodges in Africa!

Big Five game drives without the malaria-map stress: these lodges are in South Africa’s best-known malaria-free safari areas (Madikwe, Pilanesberg, and the Eastern Cape private reserves). Expect classic bush luxury, expert-guided drives, great food, and options that work brilliantly for couples and families alike.

You can't miss those Top 10 malaria-free safari lodges in Africa!

Our top picks: You can't miss those Top 10 malaria-free safari lodges in Africa!

1 Tau Game Lodge South Africa – Madikwe Game Reserve (North West)

A classic Madikwe stay that keeps things easy: morning and afternoon game drives, a proper lodge atmosphere, and plenty of “sit-back-and-stare” moments between sightings. Because Madikwe is a malaria-free safari area, it’s a smart pick for first-timers, families, and anyone wanting Big Five game viewing without overthinking health logistics.

Take me to the Hotel, at the best price! from 450 USD per night

“Big Five comfort, malaria-free simplicity.”
Best for: Big Five value safari + families
Tau Game Lodge – hotel photo
via expedia
2 Madikwe Safari Lodge South Africa – Madikwe Game Reserve (North West)

If you want “wow” factor in a malaria-free reserve, this is it: bold design, strong service, and a safari rhythm that feels effortless. Expect polished suites, beautiful shared spaces, and memorable drives in Madikwe’s big wildlife landscape. It’s the kind of lodge where the downtime is as good as the game viewing.

Take me to the Hotel, at the best price! from 1200 USD per night

“Luxury safari, built for switching off.”
Best for: Luxury all-inclusive comfort + families
Madikwe Safari Lodge – hotel photo
via expedia
3 Tuningi Safari Lodge South Africa – Madikwe Game Reserve (North West)

Tuningi nails that “small-lodge, big-experience” feel—intimate, personal, and properly safari-focused. In a malaria-free part of Madikwe, you can plan a short stay and still get a full safari hit: great guiding, relaxed meals, and the kind of evenings that end around the fire with stories of the day’s sightings.

Take me to the Hotel, at the best price! from 950 USD per night

“Intimate Madikwe magic, minus the malaria worry.”
Best for: Romantic couples + stylish boutique lodge
Tuningi Safari Lodge – hotel photo
via expedia
4 Impodimo Game Lodge South Africa – Madikwe Game Reserve (North West)

A warm, lodge-style base in a malaria-free safari area, ideal if you want a balance of comfort and time out on drives. The feel is relaxed rather than “stiff luxury,” but the experience still delivers: wildlife-rich landscapes, attentive hosting, and easy downtime by the pool between game activities.

Take me to the Hotel, at the best price! from 750 USD per night

“A friendly lodge with serious safari credentials.”
Best for: Intimate lodge + personalised guiding
Impodimo Game Lodge – hotel photo
via expedia
5 Ivory Tree Game Lodge South Africa – Pilanesberg National Park (North West)

Pilanesberg is one of South Africa’s best-known malaria-free safari options—and Ivory Tree is a strong “all-rounder” choice inside it. Expect comfortable rooms, a well-run lodge setup, and game drives that make a long weekend feel like a full safari. Great for couples and groups who want quality without going ultra-remote.

Take me to the Hotel, at the best price! from 420 USD per night

“Malaria-free Pilanesberg done properly.”
Best for: Great-value Big Five + groups/families
Ivory Tree Game Lodge – hotel photo
via expedia
6 Tshukudu Bush Lodge South Africa – Pilanesberg National Park (North West)

Tshukudu is all about atmosphere: a classic bush-lodge vibe, hearty meals, and that satisfying end-of-day feeling after a proper drive. Because Pilanesberg is malaria-free, it’s an excellent “easy safari” choice—especially if you want wildlife, sunsets, and comfort without complicated planning or long transfers.

Take me to the Hotel, at the best price! from 480 USD per night

“Classic bush-lodge charm in a malaria-free park.”
Best for: Private chalets + relaxed bush escape
Tshukudu Bush Lodge – hotel photo
via expedia
7 Black Rhino Game Lodge South Africa – Pilanesberg National Park (North West)

One of the best ways to do Pilanesberg on a sensible budget—without giving up the safari feel. You’re still in a malaria-free safari area, with strong chances of Big Five sightings, but the lodge stays grounded and relaxed. Ideal for travelers who want more game drive time and less “over-polished” formality.

Take me to the Hotel, at the best price! from 320 USD per night

“High-value safari in malaria-free Pilanesberg.”
Best for: Budget-friendly first-time safari
Black Rhino Game Lodge – hotel photo
via expedia
8 Kariega Game Reserve – Main Lodge South Africa – Eastern Cape (Kenton-on-Sea area)

The Eastern Cape is famous for malaria-free safaris—and Kariega is a top pick if you want wildlife plus a softer, greener landscape (and often excellent family-friendliness). Expect a classic reserve-lodge rhythm: guided drives, good meals, and comfortable nights. Great if you’re combining safari with a Garden Route-style trip.

Take me to the Hotel, at the best price! from 700 USD per night

“Malaria-free safari that pairs perfectly with a road trip.”
Best for: Family safari + river activities (canoe/boat)
Kariega Game Reserve - Main Lodge – hotel photo
via hotels.com
9 Ecca Lodge South Africa – Eastern Cape (Kwandwe Private Game Reserve)

A stylish, modern-feeling lodge inside the malaria-free Eastern Cape safari circuit. Ecca is a great “design + safari” combo: you get comfort, calm, and a clean contemporary look—then head out for Big Five tracking with experienced guides. It’s ideal for travelers who want luxury without the heavy “old-school lodge” aesthetic.

Take me to the Hotel, at the best price! from 900 USD per night

“Contemporary safari style in a malaria-free reserve.”
Best for: Contemporary luxury + couples/foodies
Ecca Lodge – hotel photo
via expedia
10 Shamwari Eagles Crag South Africa – Eastern Cape (Shamwari Private Game Reserve)

This is the “special occasion” entry: ultra-luxury suites, a very private feel, and safari guiding in one of the Eastern Cape’s best-known malaria-free reserves. If you want a honeymoon-level lodge where everything feels curated—from the rooms to the dining to the game drives—Eagles Crag delivers with confidence.

Take me to the Hotel, at the best price! from 2000 USD per night

“Peak Eastern Cape luxury, malaria-free and unforgettable.”
Best for: Ultra-luxury honeymoon + total privacy
Shamwari Eagles Crag – hotel photo
via hotels.com

Where these hotels are

FAQ

Are there really malaria-free safari areas in Africa?

Yes — several well-known safari regions are often marketed as malaria-free or very low-risk, especially in parts of South Africa (e.g., Madikwe, Pilanesberg, and many Eastern Cape reserves). However, “malaria-free” is not a medical guarantee and classifications can change.

Do I still need malaria tablets for these trips?

Often not, but it depends on your personal health profile, the exact reserve, seasonality, and your onward itinerary (even a short stop in a malaria-risk area changes the answer). A travel clinic or qualified health professional can advise based on your exact route.

Is wildlife viewing as good as “malaria areas” like Kruger or Serengeti?

It can be excellent. Many malaria-free reserves offer Big Five viewing and strong guiding — the experience is just different: often more curated, sometimes closer to cities, and ideal for shorter trips.

Are malaria-free lodges better for families with kids?

They’re frequently a great fit because the logistics feel simpler and parents worry less. That said, each lodge has its own child policy, minimum ages for game drives, and family room setups—check those details before booking.

What’s the best time of year to go?

In South Africa, the dry season (roughly May–October) is often best for game viewing. Shoulder seasons can offer great value and fewer crowds.

Important disclaimer (please include this):

Even in destinations commonly described as “malaria-free,” malaria risk is not guaranteed to be zero and can vary by season, local outbreaks, micro-locations, and your full itinerary. Always check the latest official health guidance for your travel dates and route (and consult a travel clinic/doctor if unsure).

More of see.africa: